It's really easy to overdo it with Soothe 2. It can be deceptive at first though... I tend to use it mostly on vocal buses as a final de-esser. The more I use it, the less of it I use too, if that makes sense

a little bit goes a long way, i try to dial in threshold till it’s barely active and i can see where its suppressing w no boosts to the eq curve, then depending on the area im trying to fix something in, i’ll dial in the curves so its only active where i want it. but i only use soothe where i hear problematic resonances, and i will try to deal with it other ways first. but its usually first in the chain or on groups.

I love it on any cymbals and certain amp sims. Also throwing it on bass sidechained to the kick has been a game changer for the lowend. Definitely easy to overdo it though

I’ve avoided it because it seemed overhyped (I don’t know though), but I do love the idea of an overhead enhancer!