We (my doctor and I) inadvertently upped my zoloft a couple weeks before the election due to early perimenopause clashing with seasonal depression. Not gonna lie, I think this week could have been MUCH worse for me had that higher dosage not kicked in right on time. The medication adjustment has in turn given me enough dopamine to get out of bed and go interact with people I enjoy and indulge in creative activities that improve my mental state. Snowball effect.