I'd been on every antidepressant doctors ever thought to give me, and finally went off the last one because it wasn't possible for me to be MORE depressed even unmedicated. But after 9 months of sobbing every day, I asked my GP if I could try wellbutrin because it also helps ADHD, and he couldn't do it (in the UK you can only get it for stopping smoking?? Only time I've regretted not smoking) but he put me on an SNRI. He said they were a step up from SSRIs 1/2 Mental Health Threads