Methylphenidate inhibits the reuptake of norepinephrine and dopamine by blocking the dopamine transporter (DAT) and norepinephrine transporter (NET). This increases the concentration of these neurotransmitters in the synaptic cleft, the space between neurons, leading to enhanced communication between brain cells. Side Effects: NDRIs can cause side effects, which may include headache, anxiety, weight loss, dry mouth, constipation, insomnia, and loss of appetite